Nanozyme-based biosensing for clinical diagnosis of COVID-19: A mini review (preprint)

Several clinical methods had been utilized for diagnosis of COVID-19 for instance, real-time reverse transcription-polymerase chain reaction (rRT-PCR), hematology examination, polymerase chain reaction (PCR), diagnostic guidelines based on clinical features, and Chest CT scans. However, the accurate current methods are time-consuming and expensive and other methods are inaccurate. To solve these drawbacks, nanozyme-based sensors have been developed for the reliable, accurate, and rapid detection of SARS-CoV-2. The main basis of these sensors is the detection of color variation of a nanozyme-mediated oxidation reaction in the presence and the absence of antigens of COVID-19. Besides, some of methods are based on probing the fluorescence of these systems as the clinical signal toward detection of SARS-CoV-2. This mini review focused on overviewing the nanozymes-based methods toward COVID-19 diagnosis. The historical background of COVID-19 was reviewed. Thereafter, the biomedical applications of nanozymes was discussed and finally, the recent progress of early diagnosis of COVID-19 based on nanozymatic systems was briefly reviewed.

Clinical and Epidemiological Features, Mechanism of Action, and Diagnosis of Global Pandemic Infectious Disease, COVID-19, and its Comparison with SARS, MERS, and H1N1: A Brief Overview (preprint)

The coronavirus disease 2019 (COVID-19) is a novel global pandemic infectious disease with higher potential for outbreaks than the other epidemic disease such as severe acute respiratory syndrome (SARS), influenza A (H1N1), and the Middle East respiratory syndrome (MERS), which identified in China on December 31, 2019. This disease is caused by a new generation of betacoronavirus termed as the 2019 novel coronavirus (2019-nCoV) or SARS-CoV-2. Although, the first report of this disease was in recent months, now, the COVID-19 is known as a global pandemics. Hence, the aim of this article is the quick review of the recent studies on the novel coronavirus disease 2019 including researches on the epidemiological parameters, mechanism of action, diagnosis, and treatment of the novel coronavirus disease, as well as clinical features of patients infected with COVID-19. Moreover, the novel COVID-19 has comprised of SARS, H1N1, and MERS.